Human IRF1 activation kit by CRISPRa

CAT#: GA102452

IRF1 CRISPRa kit - CRISPR gene activation of human interferon regulatory factor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IRF1
• Locus ID: 3659
• Kit Components:

  GA102452G1, IRF1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102452G2, IRF1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102452G3, IRF1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002198, NM_001354924, NM_001354925, NR_149068, NR_149069
• Synonyms: IRF-1; MAR
• Summary: 'The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017]'