Human MUM1 (IRF4) activation kit by CRISPRa

CAT#: GA102455

IRF4 CRISPRa kit - CRISPR gene activation of human interferon regulatory factor 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IRF4
• Locus ID: 3662
• Kit Components:

  GA102455G1, MUM1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102455G2, MUM1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102455G3, MUM1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001195286, NM_002460, NR_036585, NR_046000
• Synonyms: LSIRF; MUM1; NF-EM5; SHEP8
• Summary: 'The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]'