Human IRF5 activation kit by CRISPRa

CAT#: GA102456

IRF5 CRISPRa kit - CRISPR gene activation of human interferon regulatory factor 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IRF5
• Locus ID: 3663
• Kit Components:

  GA102456G1, IRF5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102456G2, IRF5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102456G3, IRF5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001098627, NM_001098628, NM_001098629, NM_001098630, NM_001098631, NM_001242452, NM_002200, NM_032643, NM_001347928, NM_001364314
• Synonyms: SLEB10
• Summary: 'This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]'