Human CD41 (ITGA2B) activation kit by CRISPRa

CAT#: GA102465

ITGA2B CRISPRa kit - CRISPR gene activation of human integrin subunit alpha 2b

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ITGA2B
• Locus ID: 3674
• Kit Components:

  GA102465G1, CD41 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102465G2, CD41 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102465G3, CD41 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000419
• Synonyms: BDPLT2; BDPLT16; CD41; CD41B; GP2B; GPIIb; GT; GTA; HPA3; PPP1R93
• Summary: 'This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016]'