Human Integrin alpha E (ITGAE) activation kit by CRISPRa

CAT#: GA102472

ITGAE CRISPRa kit - CRISPR gene activation of human integrin subunit alpha E

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ITGAE
• Locus ID: 3682
• Kit Components:

  GA102472G1, Integrin alpha E gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102472G2, Integrin alpha E gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102472G3, Integrin alpha E gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002208
• Synonyms: CD103; HUMINAE
• Summary: 'Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]'