Human CD51 (ITGAV) activation kit by CRISPRa

CAT#: GA102475

ITGAV CRISPRa kit - CRISPR gene activation of human integrin subunit alpha V

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ITGAV
• Locus ID: 3685
• Kit Components:

  GA102475G1, CD51 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102475G2, CD51 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102475G3, CD51 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001144999, NM_001145000, NM_002210, N83286
• Synonyms: CD51; MSK8; VNRA; VTNR
• Summary: 'The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]'