Human CD11c (ITGAX) activation kit by CRISPRa

CAT#: GA102476

ITGAX CRISPRa kit - CRISPR gene activation of human integrin subunit alpha X

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ITGAX
• Locus ID: 3687
• Kit Components:

  GA102476G1, ITGAX gRNA vector 1 in pCas-Guide-CRISPRa

  GA102476G2, ITGAX gRNA vector 2 in pCas-Guide-CRISPRa

  GA102476G3, ITGAX gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000887, NM_001286375
• Synonyms: CD11C; SLEB6
• Summary: This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]