Human CD18 (ITGB2) activation kit by CRISPRa

CAT#: GA102478

ITGB2 CRISPRa kit - CRISPR gene activation of human integrin subunit beta 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ITGB2
• Locus ID: 3689
• Kit Components:

  GA102478G1, CD18 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102478G2, CD18 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102478G3, CD18 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000211, NM_001127491, NM_001303238
• Synonyms: CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7
• Summary: 'This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]'