Human Integrin beta 7 (ITGB7) activation kit by CRISPRa

CAT#: GA102484

ITGB7 CRISPRa kit - CRISPR gene activation of human integrin subunit beta 7

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ITGB7
• Locus ID: 3695
• Kit Components:

  GA102484G1, Integrin beta 7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102484G2, Integrin beta 7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102484G3, Integrin beta 7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000889, NR_104181
• Synonyms: integrin, beta 7; integrin beta 7 subunit
• Summary: 'This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]'