Human JAK3 activation kit by CRISPRa

CAT#: GA102504

JAK3 CRISPRa kit - CRISPR gene activation of human Janus kinase 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: JAK3
• Locus ID: 3718
• Kit Components:

  GA102504G1, JAK3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102504G2, JAK3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102504G3, JAK3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000215
• Synonyms: JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK
• Summary: 'The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]'