Human JARID2 activation kit by CRISPRa

CAT#: GA102505

JARID2 CRISPRa kit - CRISPR gene activation of human jumonji and AT-rich interaction domain containing 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: JARID2
• Locus ID: 3720
• Kit Components:

  GA102505G1, JARID2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA102505G2, JARID2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA102505G3, JARID2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001267040, NM_004973
• Synonyms: JMJ
• Summary: This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012]