Human Kv1.2 (KCNA2) activation kit by CRISPRa

CAT#: GA102514

KCNA2 CRISPRa kit - CRISPR gene activation of human potassium voltage-gated channel subfamily A member 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNA2
• Locus ID: 3737
• Kit Components:

  GA102514G1, Kv1.2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102514G2, Kv1.2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102514G3, Kv1.2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001204269, NM_004974
• Synonyms: EIEE32; HBK5; HK4; HUKIV; KV1.2; MK2; NGK1; RBK2
• Summary: 'Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. [provided by RefSeq, Jul 2008]'