Human KCNE1 activation kit by CRISPRa

CAT#: GA102529

KCNE1 CRISPRa kit - CRISPR gene activation of human potassium voltage-gated channel subfamily E regulatory subunit 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNE1
• Locus ID: 3753
• Kit Components:

  GA102529G1, KCNE1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102529G2, KCNE1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102529G3, KCNE1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000219, NM_001127668, NM_001127669, NM_001127670, NM_001270402, NM_001270403, NM_001270404, NM_001270405
• Synonyms: ISK; JLNS; JLNS2; LQT2/5; LQT5; MinK
• Summary: 'The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]'