Human KCNK2 activation kit by CRISPRa

CAT#: GA102550

KCNK2 CRISPRa kit - CRISPR gene activation of human potassium two pore domain channel subfamily K member 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNK2
• Locus ID: 3776
• Kit Components:

  GA102550G1, KCNK2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102550G2, KCNK2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102550G3, KCNK2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001017424, NM_001017425, NM_014217
• Synonyms: hTREK-1c; hTREK-1e; K2p2.1; TPKC1; TREK; TREK-1; TREK1
• Summary: 'This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]'