Human KCNMA1 activation kit by CRISPRa

CAT#: GA102552

KCNMA1 CRISPRa kit - CRISPR gene activation of human potassium calcium-activated channel subfamily M alpha 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNMA1
• Locus ID: 3778
• Kit Components:

  GA102552G1, KCNMA1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102552G2, KCNMA1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102552G3, KCNMA1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001014797, NM_001161352, NM_001161353, NM_001271518, NM_001271519, NM_001271520, NM_001271521, NM_001271522, NM_001322829, NM_001322830, NM_001322832, NM_001322835, NM_001322836, NM_001322837, NM_001322838, NM_001322839, NM_002247
• Synonyms: bA205K10.1; BKTM; hSlo; KCa1.1; MaxiK; mSLO1; SAKCA; SLO; SLO-ALPHA; SLO1
• Summary: 'MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]'