Human KCNN4 activation kit by CRISPRa

CAT#: GA102557

KCNN4 CRISPRa kit - CRISPR gene activation of human potassium calcium-activated channel subfamily N member 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNN4
• Locus ID: 3783
• Kit Components:

  GA102557G1, KCNN4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102557G2, KCNN4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102557G3, KCNN4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002250
• Synonyms: hIKCa1; hKCa4; hSK4; IK; IK1; IKCA1; KCa3.1; KCA4; SK4
• Summary: 'The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]'