Human KPNA4 activation kit by CRISPRa

CAT#: GA102604

KPNA4 CRISPRa kit - CRISPR gene activation of human karyopherin subunit alpha 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KPNA4
• Locus ID: 3840
• Kit Components:

  GA102604G1, KPNA4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102604G2, KPNA4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102604G3, KPNA4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002268, NM_032771
• Synonyms: IPOA3; QIP1; SRP3
• Summary: 'The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008]'