Human Lamin B Receptor (LBR) activation kit by CRISPRa

CAT#: GA102664

LBR CRISPRa kit - CRISPR gene activation of human lamin B receptor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LBR
• Locus ID: 3930
• Kit Components:

  GA102664G1, Lamin B Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102664G2, Lamin B Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102664G3, Lamin B Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002296, NM_194442
• Synonyms: DHCR14B; LMN2R; PHA; TDRD18
• Summary: 'The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]'