Human LCK activation kit by CRISPRa

CAT#: GA102666

LCK CRISPRa kit - CRISPR gene activation of human LCK proto-oncogene, Src family tyrosine kinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LCK
• Locus ID: 3932
• Kit Components:

  GA102666G1, LCK gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102666G2, LCK gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102666G3, LCK gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001042771, NM_001330468, NM_005356
• Synonyms: IMD22; LSK; p56lck; pp58lck; YT16
• Summary: 'This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016]'