Human DNA Ligase III (LIG3) activation kit by CRISPRa

CAT#: GA102695

LIG3 CRISPRa kit - CRISPR gene activation of human DNA ligase 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LIG3
• Locus ID: 3980
• Kit Components:

  GA102695G1, DNA Ligase III gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102695G2, DNA Ligase III gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102695G3, DNA Ligase III gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002311, NM_013975
• Synonyms: LIG2
• Summary: 'This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]'