Human LMX1B activation kit by CRISPRa

CAT#: GA102718

LMX1B CRISPRa kit - CRISPR gene activation of human LIM homeobox transcription factor 1 beta

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LMX1B
• Locus ID: 4010
• Kit Components:

  GA102718G1, LMX1B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102718G2, LMX1B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102718G3, LMX1B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001174146, NM_001174147, NM_002316
• Synonyms: LMX1.2; NPS1
• Summary: 'This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]'