Human LOX activation kit by CRISPRa

CAT#: GA102722

LOX CRISPRa kit - CRISPR gene activation of human lysyl oxidase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LOX
• Locus ID: 4015
• Kit Components:

  GA102722G1, LOX gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102722G2, LOX gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102722G3, LOX gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001178102, NM_001317073, NM_002317
• Synonyms: MGC105112
• Summary: 'This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]'