Human LOXL2 activation kit by CRISPRa

CAT#: GA102724

LOXL2 CRISPRa kit - CRISPR gene activation of human lysyl oxidase like 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LOXL2
• Locus ID: 4017
• Kit Components:

  GA102724G1, LOXL2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102724G2, LOXL2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102724G3, LOXL2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002318
• Synonyms: LOR2; WS9-14
• Summary: 'This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]'