Human Lipoprotein lipase (LPL) activation kit by CRISPRa

CAT#: GA102727

LPL CRISPRa kit - CRISPR gene activation of human lipoprotein lipase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LPL
• Locus ID: 4023
• Kit Components:

  GA102727G1, LPL gRNA vector 1 in pCas-Guide-CRISPRa

  GA102727G2, LPL gRNA vector 2 in pCas-Guide-CRISPRa

  GA102727G3, LPL gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000237
• Synonyms: HDLCQ11; LIPD
• Summary: LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]