Human LTC4S activation kit by CRISPRa

CAT#: GA102750

LTC4S CRISPRa kit - CRISPR gene activation of human leukotriene C4 synthase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LTC4S
• Locus ID: 4056
• Kit Components:

  GA102750G1, LTC4S gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102750G2, LTC4S gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102750G3, LTC4S gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000897, NM_145867
• Synonyms: leukotriene C4 synthase; MGC33147
• Summary: 'The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]'