Human RP105 (CD180) activation kit by CRISPRa

CAT#: GA102758

CD180 CRISPRa kit - CRISPR gene activation of human CD180 molecule

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CD180
• Locus ID: 4064
• Kit Components:

  GA102758G1, RP105 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102758G2, RP105 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102758G3, RP105 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005582
• Synonyms: LY64; Ly78; RP105
• Summary: 'CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]'