Human MARCKS activation kit by CRISPRa

CAT#: GA102771

MARCKS CRISPRa kit - CRISPR gene activation of human myristoylated alanine rich protein kinase C substrate

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MARCKS
• Locus ID: 4082
• Kit Components:

  GA102771G1, MARCKS gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102771G2, MARCKS gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102771G3, MARCKS gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002356
• Synonyms: 80K-L; MACS; PKCSL; PRKCSL
• Summary: 'The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]'