Human SMAD3 activation kit by CRISPRa

CAT#: GA102776

SMAD3 CRISPRa kit - CRISPR gene activation of human SMAD family member 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SMAD3
• Locus ID: 4088
• Kit Components:

  GA102776G1, SMAD3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102776G2, SMAD3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102776G3, SMAD3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145102, NM_001145103, NM_001145104, NM_005902
• Synonyms: HSPC193; HsT17436; JV15-2; LDS1C; LDS3; MADH3
• Summary: 'The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. It also functions as a tumor suppressor. Mutations in this gene are associated with aneurysms-osteoarthritis syndrome and Loeys-Dietz Syndrome 3. [provided by RefSeq, Nov 2019]'