Human MAGEB1 activation kit by CRISPRa

CAT#: GA102796

MAGEB1 CRISPRa kit - CRISPR gene activation of human MAGE family member B1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MAGEB1
• Locus ID: 4112
• Kit Components:

  GA102796G1, MAGEB1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102796G2, MAGEB1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102796G3, MAGEB1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002363, NM_177404, NM_177415
• Synonyms: CT3.1; DAM10; MAGE-Xp; MAGEL1
• Summary: 'This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region, and expressed in testis and in a significant fraction of tumors of various histological types. This gene and other MAGEB members are clustered on chromosome Xp22-p21. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene, however, the full length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]'