Human MAP4 activation kit by CRISPRa

CAT#: GA102814

MAP4 CRISPRa kit - CRISPR gene activation of human microtubule associated protein 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MAP4
• Locus ID: 4134
• Kit Components:

  GA102814G1, MAP4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102814G2, MAP4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102814G3, MAP4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001134364, NM_001134365, NM_002375, NM_030884, NM_030885, NM_030983
• Synonyms: DKFZp779A1753; MGC8617
• Summary: 'The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]'