Human MCL1 activation kit by CRISPRa

CAT#: GA102843

MCL1 CRISPRa kit - CRISPR gene activation of human MCL1 apoptosis regulator, BCL2 family member

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MCL1
• Locus ID: 4170
• Kit Components:

  GA102843G1, MCL1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102843G2, MCL1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102843G3, MCL1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001197320, NM_021960, NM_182763
• Synonyms: bcl2-L-3; BCL2L3; EAT; Mcl-1; MCL1-ES; mcl1/EAT; MCL1L; MCL1S; TM
• Summary: 'This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]'