Human MDM2 activation kit by CRISPRa

CAT#: GA102858

MDM2 CRISPRa kit - CRISPR gene activation of human MDM2 proto-oncogene

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MDM2
• Locus ID: 4193
• Kit Components:

  GA102858G1, MDM2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102858G2, MDM2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102858G3, MDM2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145336, NM_001145337, NM_001145339, NM_001145340, NM_001278462, NM_002392, NM_006878, NM_006879, NM_006880, NM_006881, NM_006882, NM_001367990
• Synonyms: hdm2; HDMX; MGC5370; MGC71221
• Summary: 'This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]'