Human ME2 activation kit by CRISPRa

CAT#: GA102861

ME2 CRISPRa kit - CRISPR gene activation of human malic enzyme 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ME2
• Locus ID: 4200
• Kit Components:

  GA102861G1, ME2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102861G2, ME2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102861G3, ME2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001168335, NM_002396
• Synonyms: ODS1
• Summary: 'This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009]'