Human MGAT2 activation kit by CRISPRa

CAT#: GA102894

MGAT2 CRISPRa kit - CRISPR gene activation of human mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MGAT2
• Locus ID: 4247
• Kit Components:

  GA102894G1, MGAT2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102894G2, MGAT2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102894G3, MGAT2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001015883, NM_002408
• Synonyms: CDGS2; GLCNACTII; GNT-II; GNT2
• Summary: 'The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5' UTR may exist, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]'