Human Microsomal Glutathione S transferase 1 (MGST1) activation kit by CRISPRa

CAT#: GA102902

MGST1 CRISPRa kit - CRISPR gene activation of human microsomal glutathione S-transferase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MGST1
• Locus ID: 4257
• Kit Components:

  GA102902G1, Microsomal Glutathione S transferase 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102902G2, Microsomal Glutathione S transferase 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102902G3, Microsomal Glutathione S transferase 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001260511, NM_001260512, NM_001267598, NM_020300, NM_145764, NM_145791, NM_145792, NR_048545, NR_048546, NR_048547
• Synonyms: GST12; MGST; MGST-I
• Summary: 'The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]'