Human MICB activation kit by CRISPRa

CAT#: GA102907

MICB CRISPRa kit - CRISPR gene activation of human MHC class I polypeptide-related sequence B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MICB
• Locus ID: 4277
• Kit Components:

  GA102907G1, MICB gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102907G2, MICB gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102907G3, MICB gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001289160, NM_001289161, NM_005931
• Synonyms: PERB11.2
• Summary: 'This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]'