Human MLK3 (MAP3K11) activation kit by CRISPRa

CAT#: GA102922

MAP3K11 CRISPRa kit - CRISPR gene activation of human mitogen-activated protein kinase kinase kinase 11

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MAP3K11
• Locus ID: 4296
• Kit Components:

  GA102922G1, MLK3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102922G2, MLK3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102922G3, MLK3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002419
• Synonyms: MEKK11; MLK-3; MLK3; PTK1; SPRK
• Summary: 'The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]'