Human MMP8 activation kit by CRISPRa

CAT#: GA102937

MMP8 CRISPRa kit - CRISPR gene activation of human matrix metallopeptidase 8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MMP8
• Locus ID: 4317
• Kit Components:

  GA102937G1, MMP8 gRNA vector 1 in pCas-Guide-CRISPRa

  GA102937G2, MMP8 gRNA vector 2 in pCas-Guide-CRISPRa

  GA102937G3, MMP8 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001304441, NM_001304442, NM_002424
• Synonyms: CLG1; HNC; MMP-8; PMNL-CL
• Summary: This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]