Human MRP1 (ABCC1) activation kit by CRISPRa

CAT#: GA102972

ABCC1 CRISPRa kit - CRISPR gene activation of human ATP binding cassette subfamily C member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ABCC1
• Locus ID: 4363
• Kit Components:

  GA102972G1, MRP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102972G2, MRP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102972G3, MRP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004996, NM_019862, NM_019898, NM_019899, NM_019900, NM_019901, NM_019902
• Synonyms: ABC29; ABCC; GS-X; MRP; MRP1
• Summary: 'The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]'