Human RON (MST1R) activation kit by CRISPRa

CAT#: GA102991

MST1R CRISPRa kit - CRISPR gene activation of human macrophage stimulating 1 receptor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MST1R
• Locus ID: 4486
• Kit Components:

  GA102991G1, RON gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102991G2, RON gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102991G3, RON gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001244937, NM_001318913, NM_002447, NR_134919
• Synonyms: CD136; CDw136; PTK8; RON
• Summary: 'This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]'