Human MTHFR activation kit by CRISPRa

CAT#: GA103015

MTHFR CRISPRa kit - CRISPR gene activation of human methylenetetrahydrofolate reductase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MTHFR
• Locus ID: 4524
• Kit Components:

  GA103015G1, MTHFR gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103015G2, MTHFR gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103015G3, MTHFR gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001330358, NM_005957
• Summary: 'The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.[provided by RefSeq, Oct 2009]'