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MTHFR Human Gene Knockout Kit (CRISPR)
CAT#: KN408588
MTHFR - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.
KN2.0 knockout kit validation
KN408588 is the updated version of KN208588.
USD 1,290.00
2 Weeks*
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Specifications
| Product Data | |
| Format | 2 gRNA vectors, 1 linear donor |
| Donor DNA | EF1a-GFP-P2A-Puro |
| Symbol | MTHFR |
| Locus ID | 4524 |
| Disclaimer | The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
| Reference Data | |
| RefSeq | NM_001330358, NM_005957 |
| Summary | 'The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.[provided by RefSeq, Oct 2009]' |
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| FAQs |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| GA103015 | MTHFR CRISPRa kit - CRISPR gene activation of human methylenetetrahydrofolate reductase |
USD 1,290.00 |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.