Human Melatonin Receptor 1A (MTNR1A) activation kit by CRISPRa

CAT#: GA103026

MTNR1A CRISPRa kit - CRISPR gene activation of human melatonin receptor 1A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MTNR1A
• Locus ID: 4543
• Kit Components:

  GA103026G1, MTNR1A gRNA vector 1 in pCas-Guide-CRISPRa

  GA103026G2, MTNR1A gRNA vector 2 in pCas-Guide-CRISPRa

  GA103026G3, MTNR1A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005958
• Synonyms: MEL-1A-R; MT1
• Summary: This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]