Human MYH (MUTYH) activation kit by CRISPRa

CAT#: GA103042

MUTYH CRISPRa kit - CRISPR gene activation of human mutY DNA glycosylase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MUTYH
• Locus ID: 4595
• Kit Components:

  GA103042G1, MYH gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103042G2, MYH gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103042G3, MYH gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001048171, NM_001048172, NM_001048173, NM_001048174, NM_001128425, NM_001293190, NM_001293191, NM_001293192, NM_001293195, NM_001293196, NM_012222, NM_001350650, NM_001350651, NR_146882, NR_146883
• Synonyms: MYH
• Summary: 'This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]'