Human MYBPC3 activation kit by CRISPRa

CAT#: GA103053

MYBPC3 CRISPRa kit - CRISPR gene activation of human myosin binding protein C, cardiac

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MYBPC3
• Locus ID: 4607
• Kit Components:

  GA103053G1, MYBPC3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103053G2, MYBPC3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103053G3, MYBPC3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000256
• Synonyms: CMD1MM; CMH4; FHC; LVNC10; MYBP-C
• Summary: 'MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]'