Human MYD88 activation kit by CRISPRa

CAT#: GA103058

MYD88 CRISPRa kit - CRISPR gene activation of human MYD88 innate immune signal transduction adaptor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MYD88
• Locus ID: 4615
• Kit Components:

  GA103058G1, MYD88 gRNA vector 1 in pCas-Guide-CRISPRa

  GA103058G2, MYD88 gRNA vector 2 in pCas-Guide-CRISPRa

  GA103058G3, MYD88 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001172566, NM_001172567, NM_001172568, NM_001172569, NM_002468, NM_001365877, NM_001365876
• Synonyms: MYD88D
• Summary: This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]