Human Myosin VIIa (MYO7A) activation kit by CRISPRa

CAT#: GA103086

MYO7A CRISPRa kit - CRISPR gene activation of human myosin VIIA

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MYO7A
• Locus ID: 4647
• Kit Components:

  GA103086G1, MYO7A gRNA vector 1 in pCas-Guide-CRISPRa

  GA103086G2, MYO7A gRNA vector 2 in pCas-Guide-CRISPRa

  GA103086G3, MYO7A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000260, NM_001127179, NM_001127180, NM_001369365
• Synonyms: DFNA11; DFNB2; MYOVIIA; MYU7A; NSRD2; USH1B
• Summary: This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]