Human NCBP1 activation kit by CRISPRa

CAT#: GA103117

NCBP1 CRISPRa kit - CRISPR gene activation of human nuclear cap binding protein subunit 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NCBP1
• Locus ID: 4686
• Kit Components:

  GA103117G1, NCBP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103117G2, NCBP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103117G3, NCBP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002486, NM_001351504, NM_001351505, NM_001351506, NM_001351507
• Synonyms: CBP80; NCBP; Sto1
• Summary: 'The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008]'