Human NFH (NEFH) activation kit by CRISPRa

CAT#: GA103165

NEFH CRISPRa kit - CRISPR gene activation of human neurofilament heavy

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NEFH
• Locus ID: 4744
• Kit Components:

  GA103165G1, NFH gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103165G2, NFH gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103165G3, NFH gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_021076
• Synonyms: NFH
• Summary: 'Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008]'