Human Neuraminidase (NEU1) activation kit by CRISPRa

CAT#: GA103173

NEU1 CRISPRa kit - CRISPR gene activation of human neuraminidase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NEU1
• Locus ID: 4758
• Kit Components:

  GA103173G1, Neuraminidase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103173G2, Neuraminidase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103173G3, Neuraminidase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000434
• Synonyms: NANH; NEU; SIAL1
• Summary: 'The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. [provided by RefSeq, Jul 2008]'